5 Best Face Serums and Creams for Anti-aging and Glowing Skin

As you age, your body produces less elastin and collagen -- substances that allow the skin to maintain its supple, smooth and youthful appearance. The skin loses fat, becomes thinner and begins to sag, making it susceptible to fine lines and wrinkles. 

Your skin starts to age around the age of 20 and experts agree that starting the road to prevention early is the best way to reduce signs of premature aging. 

According to research published in Clinical, Cosmetic and Investigational Dermatology, face serums for anti-aging containing L-ascorbic acid (a derivative of vitamin C) are effective in reversing changes in collagen and elastin production as a result of aging [1]. Participants also reported an increase in skin moisture, skin brightness and a decline in wrinkles after continued use of anti-aging serums.

It is important to understand that the goal of antiaging isn’t to look younger but to feel beautiful at any age. Products containing research-backed active ingredients can help you feel comfortable in your own skin. We’ve rounded up some of the best face serums and anti-aging creams with fabulous key ingredients and their benefits 

  1. GloxiniaLife by Dr. Calle Tretinol 0.50% Serum- Acne & Acne Scar Treatment- Wrinkle Repair-Lightener

According to research published in Derma Endocrinology, wrinkles and skin, pigmentary changes are directly linked with premature photo-aging caused by unprotected exposure to the sun [2]. Therefore, your first step to reducing signs of aging is using sunscreen every day -- even when you’re indoors. Next, you’ll need to include a product that reduces signs of photodamage, such as Dr. Calle Tretinol 0.50% Serum.

This face serum is excellent for individuals with wrinkles and fine lines, melasma, dark spots from breakouts and acne scars. It contains a patented Retinoid complex named Tretinol, which also includes vitamins C and E. Vitamins C and E are the most important antioxidants for anti-aging and glowing skin because of their small molecular weight. This allows the molecules to penetrate deep through the skin and have a substantial effect on your skin’s structure [3].

Vitamin C has been proven to induce the production of Col-1, Col-3, and enzymes vital for the production of collagen. It also supports the formation of matrix metalloproteinase (MMP) 1 (collagenase 1) inhibitors that block the breakdown of collagen peptides in the skin [4]. 

Clinical studies have also proven that face serums that contain vitamin C and E together offer more antioxidative protection compared to vitamin C and E individually [5], [6].

In addition to stimulating collagen and elastin production, the facial serum also helps reduce acne breakouts and acne scars by preventing skin pores from getting clogged by dead skin cells. 

2. GloxiniaLife by Dr. Calle Retinol 0.25% Serum- Acne Treatment, Wrinkle Repair, Dark Spot Corrector

Aging, oxidative stress and UV radiation, reduce the formation of collagen, significantly impacting our skin’s natural glow and suppleness. 

Vitamin A derivatives, such as retinol, play a powerful role in improving fine lines and skin laxity [7]. This wrinkle repair serum containing retinol promotes the deposition of new collagen and at the same time, prevents the breakdown of collagen by increasing levels of Type 1 procollagen. 

Topical antioxidants work best when they’re combined together in facial serums for anti-aging. Therefore, the product contains a combination of vitamin C, Coenzyme Q10 and Squalane that contain antioxidant properties, reduce inflammation and effectively treat photodamaged skin.

If you’re looking for a firming, anti-aging serum that also doubles as an acne scar and dark spot remover, the Dr. Calle Retinol 0.25% Serum is a must-try.

3. GloxiniaLife by Dr. Calle Citrus Kojic Acid - Natural Skin Lightening For Dark Spots & Melasma

Kojic acid is a potent UV protector and an inhibitor for melanin formation and hyperpigmentation due to its tyrosinase inhibitory activity [8]. Research has proven that kojic acid is a safe and nontoxic lightening agent that can treat hyperpigmentation and dark spots caused by excessive exposure to UV radiation, free radicals and metal ions [9].

Kojic acid is a natural plant-based depigmenting substance that functions similarly to hydroquinone. However, the latter may not be safe and can lead to a rare condition called Ochronosis [10].

Therefore, if you’re looking for a cream for glowing skin minus chemical compounds that may harm your protective barrier, this product is your best match.

4. GloxiniaLife by Dr. Calle Vita C E Ferulic Acid- Vitamin C & E with Hyaluronic Acid Serum

If you’re on the lookout for anti-wrinkle serums containing hyaluronic acid, you’re in luck. Not only does this product contain the skin-plumping activity offered by hyaluronic acid, it also contains Vitamins C and E -- a combination that has proven to reduce photoaging, melasma and skin inflammation.

Aging and photodamage cause epidermal hyaluronic acid to degenerate substantially [11]. Hyaluronic acid is a major component of your skin matrix that promotes tissue repair, wound healing, space-filling, shock absorption, lubrication and protein exclusion [12]. Hyaluronic acid also stimulates the production of collagen, elastin, and inhibitor of matrix metalloproteinase-1, making it the “gold standard” ingredient for skin rejuvenation.

This wrinkle treatment also contains ferulic acid, which helps stabilize vitamin C and reinforces its photoprotective properties. Studies show that ferulic acid offers twice the amount of photoprotection when used in conjunction with vitamins C and E [13].

5. GloxiniaLife by Dr. Calle Radiant-C Cream- Vitamin C Enriched Cream, Anti-Aging & Skin Lightener

Vitamin C is a powerful antioxidant that donates electrons, protects the skin against UV damage, increases collagen production by boosting fibroblast activity, inhibits free radical activity and stabilizes collagen crosslinking [14], [15], [16]. It also regenerates vitamin E, which is another important antioxidant that fights skin aging [17].


This vitamin C cream contains a blend of 5 self-stabilized, bioavailable forms of Vitamin C, enabling it to be readily absorbed into the skin. Vitamin C is an important component of anti-aging because it stimulates the production of collagen, thereby tightening the skin and reducing the appearance of fine lines and wrinkles. It also helps soothe inflammation associated with acne and brightens mature skin, offering it a natural, radiant glow.


Your collagen and elastin production starts to decline in your 20s. Therefore, dermatologists recommend developing an anti-aging skincare regime early to prevent signs of premature aging. Anti-aging is a booming business, so the number of products you come across may overwhelm you in the beginning. As a general rule, always read labels and keep a lookout for key ingredients in face serums, such as vitamins C and E, retinol, hyaluronic acid and plant-based skin lighteners such as kojic acid.


  1. Garre A et al. Antiaging effects of a novel facial serum containing L-ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: ex vivo skin explant studies and in vivo clinical studies in women. January 2018. https://www.dovepress.com/antiaging-effects-of-a-novel-facial-serum-containing-l-ascorbic-acid-p-peer-reviewed-article-CCID
  2. Ruta Ganceviciene et al. Skin anti-aging strategies. 01 Jul 2012. https://www.tandfonline.com/doi/full/10.4161/derm.22804
  3. Bissett DL et al.Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. 2004 Oct. https://www.ncbi.nlm.nih.gov/pubmed/18492135
  4. Nusgens BV et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis.2001 Jun. https://www.ncbi.nlm.nih.gov/pubmed/11407971
  5. Hautarzt. [Anti-aging creams. What really helps?]. 2011 Aug. https://www.ncbi.nlm.nih.gov/pubmed/21755353
  6. Murray JC et al. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. 2008. https://www.ncbi.nlm.nih.gov/pubmed/18603326
  7. Baumann L. Skin ageing and its treatment. 2007. https://www.ncbi.nlm.nih.gov/pubmed/17200942 
  8. Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. 2018. https://www.ncbi.nlm.nih.gov/pubmed/30537675
  9. Ahmad Firdaus B. Lajis, 1 Muhajir Hamid, 2 , 3 and Arbakariya B. Ariff Depigmenting Effect of Kojic Acid Esters in Hyperpigmented B16F1 Melanoma Cells. 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468271/
  10. Vijay Gandhi, Prashant Verma, and Geetanjali Naik. Exogenous ochronosis After Prolonged Use of Topical Hydroquinone (2%) in a 50-Year-Old Indian Female. 2012 September. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482806/
  11. Elsner P, Maibach HI. Cosmeceuticals and Active Cosmetics: Drugs versus Cosmetics (2nd edn). 2005. https://www.taylorfrancis.com/books/9780429192258
  12. Laurent TC, Fraser JR. Hyaluronan. 1992. https://www.ncbi.nlm.nih.gov/pubmed/1563592
  13. Fu-Hsiung Lin et al. Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin. Oct 2005. https://www.jidonline.org/article/S0022-202X(15)32491-X/fulltext
  14. Chaudière J, Ferrari-Iliou R. Intracellular antioxidants: from chemical to biochemical mechanisms.1999. https://www.ncbi.nlm.nih.gov/pubmed/10541450
  15. Grinnell F, Fukamizu H, Pawelek P, Nakagawa S. Collagen processing, crosslinking, and fibril bundle assembly in matrix produced by fibroblasts in long-term cultures supplemented with ascorbic acid. 1989. https://www.ncbi.nlm.nih.gov/pubmed/2924799
  16.  Boyera N, Galey I, Bernard B. Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. 1998.https://www.ncbi.nlm.nih.gov/pubmed/18505499 
  17. Chaudière J, Ferrari-Iliou R. Intracellular antioxidants: from chemical to biochemical mechanisms.1999. https://www.ncbi.nlm.nih.gov/pubmed/10541450

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